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Definitions and weighted scores of comorbidities by the HSCT–specific comorbidity index (HCT-CI)
Definitions (HCT-CI weighted scores )
Arrhythmia (1)
Atrial fibrillation or flutter, sick sinus syndrome, or ventricular arrhythmias
Cardiac (1)
Coronary artery disease,* congestive heart failure,myocardial infarction, or EF of 
50%
Inflammatory bowel disease (1)
Crohn's disease or ulcerative colitis (1)
Diabetes (1)
Requiring treatment with insulin or oral hypoglycemic,
but not controlled with diet alone
Cerebrovascular disease (1)
Transient ischemic attacks or cerebrovascular acciden
Psychiatric disturbance (1)
Depression/anxiety requiring psychiatric
consult and/or treatment at the time of HCT
Hepatic (1)
Mild chronic hepatitis, bilirubin >ULN to 1.5x ULN,
or AST/ALT >ULN to 2.5x ULN
Obesity (1)
Patients with a BMI of >35 for adults or with
BMI-for-age percentile of 
95th percentile for children
Infection (1)
Documented infection or fever of unknown etiology requiring
antimicrobial treatment before, during,
and after the start of conditioning regimen
Rheumatologic (2)
SLE, RA, polymyositis, mixed CTD,
and polymyalgia rheumatica
Peptic ulcer (2)
Requiring treatment
Moderate/severe renal (2)
Serum creatinine >2 mg/dL
, on dialysis,
or prior to renal transplantation
Moderate pulmonary (2)
DLco and/or FEV1 66%-80% or dyspnea
on slight activity
Prior solid malignancy (3)
Treated at any time point in the patient's history,
excluding nonmelanoma skin cancer
Heart valve disease (3)
Except asymptomatic mitral valve prolapse
Severe pulmonary (3)
DLco and/or FEV1 
65% or dyspnea at rest or
requiring oxygen
Moderate/severe hepatic (3)
Liver cirrhosis, bilirubin >1.5x ULN,
or AST/ALT >2.5x ULN
Data are from Sorror et al.12
* One or more vessel-coronary artery stenoses, requiring medical treatment, stent, or bypass graft.
